专家资源

YINGBO LIN, PH.D Dept. of Oncology and Pathology, Cancer Centrum Karolinska, Karolinska Hospital, Sweden E-mail: linyingbo@gmail.com; Yingbo.Lin@ki.se, Tel: +46(0)700226288; +86 14753583427 Dr. Yingbo Lin has 15 years experience from academic and scientific research in China and the Nordics, where he has specialised in cancer studies. He has conducted research at Ocean University Qingdao, Uppsala University and Karolinska Institute. Alongside his research, Yingbo has worked as an adviser for Chinese Science Parks and Government Agencies in the Nordics. Working with communication on Chinese industrial policies, policy support and regulations for newly established foreign businesses in China. This combined with his experience from Chinese and Nordic research institutes; Yingbo has developed an expertise in regulatory systems and policies for foreign innovation projects and cooperation in China. CURRENT POSITIONS Assistant Professor | Department of Oncology-Pathology, Karolinska Institute Founder and CEO | Sinorvodic Investment and Consulting AB Executive President | Nordic Chinese Association for Innovation and Entrepreneurship General Manager | Suzhou Centre for International Innovation and Entrepreneurship in Sweden Senior Advisor | Shenzhen China-Europe Innovation Centre EDUCATION • 2004.9-2009.7 Ph.D at Lab of Pathology and Immunology of Aquatic Animals, Dept. of Aquaculture, Fisheries College, Ocean University of China, China. • 2008.1-2009.3 Joint Ph.D candidate at Cancer Centre Karolinska, Karolinska Institute, Sweden. • 2007.9-2007.11 Guest researcher at Evolutionary Biology Centre, Uppsala University, Sweden. • 2000.9-2003.7 Bachelor Degree in Biology Science at Dept. of Biology, Biology College, Ocean University of China, China. ACADEMIC OUTPUTS Lin Y, Seger N, Chen Y, Hesla A, Wejde J, Ghaderi M, Tsagkozis P, Larsson O, Haglund F. hTERT promoter mutations in chondrosarcomas associate with progression and disease-related mortality, Modern Pathology, 2018 31: 1834–1841. Lin Y, van Duyvenvoorde HA, Liu H, Yang C, Warsito D, Yin C, Kant SG, Haglund F, Wit JM, Larsson O. Characterization of an activating R1353H insulin-like growth factor 1 receptor variant in a male with extreme tall height. Eur J Endocrinol. 2018 Aug;179(2):85-95. doi: 10.1530/EJE-18-0176. Epub 2018 May 22. Lin Y, Seger N, Tsagkozis P, Hesla AC, Ghaderi M, Chen Y, Ehnman M, Warsito D, Wejde J, Larsson O, Haglund F. Telomerase promoter mutations and copy number alterations in solitary fibrous tumours. J Clin Pathol. 2018 Apr 27. pii: jclinpath-2018-205132. doi: 10.1136/jclinpath-2018-205132. Lin Y (Corresponding Author), Liu H, Waraky A, Haglund F, Agarwal P, Jernberg-Wiklund H, Warsito D, Larsson O. SUMO-modified insulin-like growth factor 1 receptor (IGF-1R) increases cell cycle progression and cell proliferation. Journal of Cellular Physiology. 2017: DOI:10.1002/jcp.25818 Xie B, He X, Guo G, Zhang X, Li J, Liu J, Lin Y (Corresponding Author). High-throughput screening identified mitoxantrone to induce death of hepatocellular carcinoma cells with autophagy involvement. Biochem Biophys Res Commun. 2020 Jan 1;521(1):232-237. doi: 10.1016/j.bbrc.2019.10.114. Packham S, Lin Y (Co-first author), Zhao Z, Warsito D, Rutishauser D, Larsson O. The Nucleus-Localized Epidermal Growth Factor Receptor Is SUMOylated. Biochemistry. 2015 Aug 25;54(33):5157-66. Trocmé E, Mougiakakos D, Johansson CC, All-Eriksson C, Economou MA, Larsson O, Seregard S, Kiessling R, Lin Y (Corresponding Author). Nuclear HER3 is associated with favorable overall survival in uveal melanoma. Int J Cancer. 2012 Mar 1;130(5):1120-7. Lin Y, Zhan W, Li Q, Zhang Z, Wei X, Sheng X. Ontogenesis of haemocytes in shrimp (Fenneropenaeus chinensis) studied with probes of monoclonal antibody. Dev Comp Immunol. 2007;31(11):1073-81. Waraky A, Lin Y, Warsito D, Haglund F, Aleem E, Larsson O. Nuclear insulin-like growth factor 1 receptor phosphorylates proliferating cell nuclear antigen and rescues stalled replication forks after DNA damage. J Biol Chem. 2017 Nov 3;292(44):18227-18239. doi: 10.1074/jbc.M117.781492. Epub 2017 Sep 18. Zhao Z, Wang S, Lin Y, Miao Y, Zeng Y, Nie Y, Guo P, Jiang G, Wu J. Epithelial-mesenchymal transition in cancer: Role of the IL-8/IL-8R axis. Oncol Lett. 2017 Jun;13(6):4577-4584. doi: 10.3892/ol.2017.6034. Epub 2017 Apr 13. Warsito D, Lin Y, Gnirck AC, Sehat B, Larsson O. Nuclearly translocated insulin-like growth factor 1 receptor phosphorylates histone H3 at tyrosine 41 and induces SNAI2 expression via Brg1 chromatin remodeling protein. Oncotarget. 2016 Jul 5;7(27):42288-42302. Strömberg T, Feng X, Delforoush M, Berglund M, Lin Y, Axelson M, Larsson O, Georgii-Hemming P, Lennartsson J, Enblad G. Picropodophyllin inhibits proliferation and survival of diffuse large B-cell lymphoma cells. Med Oncol. 2015 Jul;32(7):188. Packham S, Warsito D, Lin Y, Sadi S, Karlsson R, Sehat B, Larsson O. Nuclear translocation of IGF-1R via p150(Glued) and an importin-β/RanBP2-dependent pathway in cancer cells. Oncogene. 2015 Apr 23;34(17):2227-38. Ibarra C, Vicencio JM, Estrada M, Lin Y, Rocco P, Rebellato P, Munoz JP, Garcia-Prieto J, Quest AF, Chiong M, Davidson SM, Bulatovic I, Grinnemo KH, Larsson O, Szabadkai G, Uhlén P, Jaimovich E, Lavandero S. Local control of nuclear calcium signaling in cardiac myocytes by perinuclear microdomains of sarcolemmal insulin-like growth factor 1 receptors. Circ Res. 2013 Jan 18;112(2):236-45. Feng X, Aleem E, Lin Y, Axelson M, Larsson O, Strömberg T. Multiple antitumor effects of picropodophyllin in colon carcinoma cell lines: clinical implications. Int J Oncol. 2012 Apr;40(4):1251-8. Deng H, Lin Y, Badin M, Vasilcanu D, Strömberg T, Jernberg-Wiklund H, Sehat B, Larsson O. Over-accumulation of nuclear IGF-1 receptor in tumor cells requires elevated expression of the receptor and the SUMO-conjugating enzyme Ubc9. Biochem Biophys Res Commun. 2011 Jan 14;404(2):667-71. Sehat B, Tofigh A, Lin Y, Trocmé E, Liljedahl U, Lagergren J, Larsson O. SUMOylation mediates the nuclear translocation and signaling of the IGF-1 receptor. Sci Signal. 2010 Feb 9;3(108):ra10. RESEARCH SUPPERVISONAS • Co-supervisor of two Ph.D student: Dudi Warsito (2009-2014), Sylvia Packham (2010-2015) and Yi Chen (2018 till now) ACCOMPLISHED SOCIAL RPROJECTS 2019, “Win-the-Future” Venture Contest (Sweden Division), head of the organization committee 2019, the 2nd China-Europe Innovation Cooperation Summit & Technology Start-up Forum, member of the organization committee 2019, China (Shenzhen) Innovation & Entrepreneurship International Competition (IEIC) Sweden Division, member of the organization committee 2018, the 10th “Win in Suzhou” Venture Contest (Sweden Division), head of the organization committee. 2018, the 1st China-Europe Innovation Cooperation Summit & Technology Start-up Forum, member of the organization committee.