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Mouse Model for NASH and Steatotic HCC

来源:http://www.ibridgenetwork.org 时间:2014.09.28

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and a leading cause of cancer deaths. The majority of HCC develops in the context of chronic liver disease, and many of these patients are obese and suffer from non-alcoholic steatohepatitis (NASH). There is a need to find an appropriate model to study development of NASH and to be used for testing treatments for this disease.


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UCSD researchers have developed a genetically modified mouse model for use in identifying, testing, and evaluating treatments that prevent or ameliorate NASH and attenuate progression of HCC. These mice are fed a high fat diet and develop liver disease whose features are nearly identical to those of human NASH. Further, after these mice develop NASH, they go on to develop HCC, as is seen in the human disease. The timing of NASH development is within 24 weeks and HCC develops within 40 weeks.

http://www.ibridgenetwork.org/ucsd/mouse-model-for-nash-and-steatotic-hcc?categories=39

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