登录 |  中文
首页 / 新闻 / Breakthrough

Breakthrough

A Novel Diagnostic/Prognostic Marker and Therapeutic Target for Prostate Cancer

来源:http://gtp.autm.net 时间:2014.08.08

One of the critical goals of prostate cancer research is to identify the tumors that need to be aggressively treated. Unfortunately, after decades of intensive research, there is still no prognostic marker to distinguish indolent and aggressive tumors. Using unbiased bioinformatics analysis of a human prostate cancer gene expression data set, researchers at Baylor College of Medicine have identified a Gene R that can be used as a diagnostic/prognostic marker and possibly a therapeutic target.


(Picture from http://en.wikipedia.org)

Gene R is not expressed in normal human prostate tissues or benign prostatic hyperplasia (BPH). However, it is expressed in two-thirds of primary human prostate tumors at both mRNA and protein levels and thus can be used as a diagnostic marker. More importantly, Gene R positive prostate cancer patients showed longer disease-free survival, highlighting its prognostic value. Clinical treatment strategies can be personalized based on expression levels of Gene R alone or together with ERG (ETS-related gene), a well-known prostate cancer biomarker. The inventors report that patients with Gene R positive, ERG negative tumors have the best prognosis. These individuals may receive watchful waiting. On the other hand, individuals with Gene R negative ERG positive prostate tumors have the worst prognosis. These individuals need to be aggressively treated, such as radical prostatectomy. Last but not least, Gene R contains drug-targetable functional domains making it a potential therapeutic target for prostate cancer.

http://gtp.autm.net/technology/view/50498



分享:  

Copyright © 2014    国际技术转移协作网络    京ICP备12048104号-4

北京市朝阳区芍药居北里101号世奥国际中心A座 1117室

联系我们:010-84351699    关于我们