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Treating Fungal Infections with New Forazoline Compounds

From: http://www.warf.org Time:2014.07.11

Fungal infections range in severity from common athlete’s foot to life-threatening illness. Treatment can be very expensive. The cost of treating systemic Candida yeast infections exceeds $31,000 per patient in the United States. This fungus is responsible for afflictions like diaper rash, vaginal yeast infection and oral thrush.

Finding new agents to fight Candida and other fungal infections could be globally beneficial and profitable.

(Picture from http://baike.baidu.com)

UW–Madison researchers have developed antifungal compounds isolated from Actinomadura, a bacterium found in a species of sea squirt. After extensive chemical isolation and characterization, the researchers identified a new class of compounds called ‘Forazolines’ that possess antifungal activity. Forazoline A was shown to be effective against Candida albicans in a mouse model.

In a mouse model of C. albicans infection, Forazoline A was shown to reduce kidney fungal load by a log after eight hours of treatment. No toxic effects were observed at the concentrations used.


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